Titanium and fluoride-containing hydroxyl apatite were synthesized through precipitation method following by a hydrothermal stage at 100oC for 6 hours. XRD analysis of the sample scalcinedat650oC for 1 hour revealed that all samples have pure apatite structure. The existence of Fluoride substitution in apatite structure was confirmed by FTIR(Fourier Transform Infrared Spectroscopy) analysis. Surfaces of the samples were studied by zeta potential measurements. Investigating cell parameter and also FWHM (Full Width at Half Maximum) of phosphate v1 peak in Raman spectra showed some different behaviour in samples with titanium and high fluoride concentration attributed to different position of titanium in these samples. Scanning electron microscopy (SEM) was used for investigating the morphology of samples. The Morphology of particles was not affected by adding titanium and fluoride.